Ontology highlight
ABSTRACT:
SUBMITTER: Nadeau NJ
PROVIDER: S-EPMC2248353 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Nadeau Nicola J NJ Minvielle Francis F Ito Shin'ichi S Inoue-Murayama Miho M Gourichon David D Follett Sarah A SA Burke Terry T Mundy Nicholas I NI
Genetics 20080201 2
ASIP is an important pigmentation gene responsible for dorsoventral and hair-cycle-specific melanin-based color patterning in mammals. We report some of the first evidence that the avian ASIP gene has a role in pigmentation. We have characterized the genetic basis of the homozygous lethal Japanese quail yellow mutation as a >90-kb deletion upstream of ASIP. This deletion encompasses almost the entire coding sequence of two upstream loci, RALY and EIF2B, and places ASIP expression under control o ...[more]