Isoelectric points of multi-domain proteins.
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ABSTRACT:
SUBMITTER: Carugo O
PROVIDER: S-EPMC2248714 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Publications
Although the distribution of protein isoelectric points is multi-modal, large proteins show isoelectric points less variable than small proteins and their isoelectric points tend to converge to a unique value, close to the pH of the milieu in which the proteins are functional, as far as the protein dimension increases. This study demonstrates that large proteins, which contain more than a single domain, do have isoelectric points less variable than small proteins, which contains a single domain. ...[more]
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