Crystal structure of the Yersinia type III secretion protein YscE.
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ABSTRACT:
SUBMITTER: Phan J
PROVIDER: S-EPMC2253283 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
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Crystal structure of the Yersinia type III secretion protein YscE.
Phan Jason J Austin Brian P BP Waugh David S DS
Protein science : a publication of the Protein Society 20051001 10
The plague-causing bacterium Yersinia pestis utilizes a contact-dependent (type III) secretion system (T3SS) to transport virulence factors from the bacterial cytosol directly into the interior of mammalian cells where they interfere with signal transduction pathways that mediate phagocytosis and the inflammatory response. The type III secretion apparatus is composed of 20-25 different Yersinia secretion (Ysc) proteins. We report here the structure of YscE, the smallest Ysc protein, which is a d ...[more]
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