Ontology highlight
ABSTRACT:
SUBMITTER: Fleming PJ
PROVIDER: S-EPMC2253345 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Fleming Patrick J PJ Rose George D GD
Protein science : a publication of the Protein Society 20050603 7
Evidence from proteins and peptides supports the conclusion that intrapeptide hydrogen bonds stabilize the folded form of proteins. Paradoxically, evidence from small molecules supports the opposite conclusion, that intrapeptide hydrogen bonds are less favorable than peptide-water hydrogen bonds. A related issue-often lost in this debate about comparing peptide-peptide to peptide- water hydrogen bonds-involves the energetic cost of an unsatisfied hydrogen bond. Here, experiment and theory agree ...[more]