Ontology highlight
ABSTRACT:
SUBMITTER: Alarcon M
PROVIDER: S-EPMC2253955 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Alarcón Maricela M Abrahams Brett S BS Stone Jennifer L JL Duvall Jacqueline A JA Perederiy Julia V JV Bomar Jamee M JM Sebat Jonathan J Wigler Michael M Martin Christa L CL Ledbetter David H DH Nelson Stanley F SF Cantor Rita M RM Geschwind Daniel H DH
American journal of human genetics 20080101 1
Autism is a genetically complex neurodevelopmental syndrome in which language deficits are a core feature. We describe results from two complimentary approaches used to identify risk variants on chromosome 7 that likely contribute to the etiology of autism. A two-stage association study tested 2758 SNPs across a 10 Mb 7q35 language-related autism QTL in AGRE (Autism Genetic Resource Exchange) trios and found significant association with Contactin Associated Protein-Like 2 (CNTNAP2), a strong a p ...[more]