Modulation of purinergic signaling by NPP-type ectophosphodiesterases.
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ABSTRACT:
SUBMITTER: Stefan C
PROVIDER: S-EPMC2254485 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
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Modulation of purinergic signaling by NPP-type ectophosphodiesterases.
Stefan Cristiana C Jansen Silvia S Bollen Mathieu M
Purinergic signalling 20060601 2
Extracellular nucleotides can elicit a wide array of cellular responses by binding to specific purinergic receptors. The level of ectonucleotides is dynamically controlled by their release from cells, synthesis by ectonucleoside diphosphokinases and ectoadenylate kinases, and hydrolysis by ectonucleotidases. One of the four structurally unrelated families of ectonucleotidases is represented by the NPP-type ectophosphodiesterases. Three of the seven members of the NPP family, namely NPP1-3, are k ...[more]
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