Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi Y
PROVIDER: S-EPMC2254521 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Takahashi Yoshinori Y Coppola Domenico D Matsushita Norimasa N Cualing Hernani D HD Sun Mei M Sato Yuya Y Liang Chengyu C Jung Jae U JU Cheng Jin Q JQ Mulé James J JJ Pledger W Jack WJ Wang Hong-Gang HG
Nature cell biology 20070923 10
Autophagy is an evolutionarily conserved 'self-eating' process. Although the genes essential for autophagy (named Atg) have been identified in yeast, the molecular mechanism of how Atg proteins control autophagosome formation in mammalian cells remains to be elucidated. Here, we demonstrate that Bif-1 (also known as Endophilin B1) interacts with Beclin 1 through ultraviolet irradiation resistance-associated gene (UVRAG) and functions as a positive mediator of the class III PI(3) kinase (PI(3)KC3 ...[more]