Ontology highlight
ABSTRACT:
SUBMITTER: Kim TD
PROVIDER: S-EPMC2254543 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Kim Theo D TD Terwey Theis H TH Zakrzewski Johannes L JL Suh David D Kochman Adam A AA Chen Megan E ME King Chris G CG Borsotti Chiara C Grubin Jeremy J Smith Odette M OM Heller Glenn G Liu Chen C Murphy George F GF Alpdogan Onder O van den Brink Marcel R M MR
Blood 20080104 5
Dendritic cells (DCs) are considered critical for the induction of graft-versus-host disease (GVHD) after bone marrow transplantation (BMT). In addition to their priming function, dendritic cells have been shown to induce organ-tropism through induction of specific homing molecules on T cells. Using adoptive transfer of CFSE-labeled cells, we first demonstrated that alloreactive T cells differentially up-regulate specific homing molecules in vivo. Host-type dendritic cells from the GVHD target o ...[more]