Ontology highlight
ABSTRACT:
SUBMITTER: Sykiotis GP
PROVIDER: S-EPMC2257869 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Sykiotis Gerasimos P GP Bohmann Dirk D
Developmental cell 20080101 1
Keap1/Nrf2 signaling defends organisms against the detrimental effects of oxidative stress and has been suggested to abate its consequences, including aging-associated diseases like neurodegeneration, chronic inflammation, and cancer. Nrf2 is a prominent target for drug discovery, and Nrf2-activating agents are in clinical trials for cancer chemoprevention. However, aberrant activation of Nrf2 by keap1 somatic mutations may contribute to carcinogenesis and promote resistance to chemotherapy. To ...[more]