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Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds.

ABSTRACT: Tubulin is essential to eukaryotic cells and is targeted by several antineoplastics, herbicides, and antimicrobials. We demonstrate that Acanthamoeba spp. are resistant to five antimicrotubule compounds, unlike any other eukaryote studied so far. Resistance correlates with critical amino acid differences within the inhibitor binding sites of the tubulin heterodimers.

SUBMITTER: Henriquez FL

PROVIDER: S-EPMC2258519 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature

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Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds.

Henriquez Fiona L FL Ingram Paul R PR Muench Stephen P SP Rice David W DW Roberts Craig W CW

Antimicrobial agents and chemotherapy 20071210 3

Tubulin is essential to eukaryotic cells and is targeted by several antineoplastics, herbicides, and antimicrobials. We demonstrate that Acanthamoeba spp. are resistant to five antimicrotubule compounds, unlike any other eukaryote studied so far. Resistance correlates with critical amino acid differences within the inhibitor binding sites of the tubulin heterodimers. ...[more]

PMID: 18070965

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