Spontaneous recovery in acute human hepatitis C virus infection: functional T-cell thresholds and relative importance of CD4 help.
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ABSTRACT:
SUBMITTER: Smyk-Pearson S
PROVIDER: S-EPMC2258714 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
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Spontaneous recovery in acute human hepatitis C virus infection: functional T-cell thresholds and relative importance of CD4 help.
Smyk-Pearson Susan S Tester Ian A IA Klarquist Jared J Palmer Brent E BE Pawlotsky Jean-Michel JM Golden-Mason Lucy L Golden-Mason Lucy L Rosen Hugo R HR
Journal of virology 20071128 4
The mechanisms mediating protective immunity to hepatitis C virus (HCV) infection are incompletely understood because early infection in humans is rarely identified, particularly in those individuals who subsequently demonstrate spontaneous virus eradication. We have established a large national network of patients with acute HCV infection. Here, we comprehensively examined total HCV-specific CD4(+) and CD8(+) T-cell responses and identified functional T-cell thresholds that predict recovery. In ...[more]
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