Ontology highlight
ABSTRACT:
SUBMITTER: Pitzalis M
PROVIDER: S-EPMC2259316 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Pitzalis Maristella M Zavattari Patrizia P Murru Raffaele R Deidda Elisabetta E Zoledziewska Magdalena M Murru Daniela D Moi Loredana L Motzo Costantino C Orrù Valeria V Costa Gianna G Solla Elisabetta E Fadda Elisabetta E Schirru Lucia L Melis Maria Cristina MC Lai Marina M Mancosu Cristina C Tranquilli Stefania S Cuccu Stefania S Rolesu Marcella M Secci Maria Antonietta MA Corongiu Daniela D Contu Daniela D Lampis Rosanna R Nucaro Annalisa A Pala Gavino G Pacifico Adolfo A Maioli Mario M Frongia Paola P Chessa Margherita M Ricciardi Rossella R Lostia Stanislao S Marinaro Anna Maria AM Milia Anna Franca AF Landis Novella N Zedda Maria Antonietta MA Whalen Michael B MB Santoni Federico F Marrosu Maria Giovanna MG Devoto Marcella M Cucca Francesco F
BMC medical genetics 20080120
<h4>Background</h4>The Mediterranean island of Sardinia has a strikingly high incidence of the autoimmune disorders Type 1 Diabetes (T1D) and Multiple Sclerosis (MS). Furthermore, the two diseases tend to be co-inherited in the same individuals and in the same families. These observations suggest that some unknown autoimmunity variant with relevant effect size could be fairly common in this founder population and could be detected using linkage analysis.<h4>Methods</h4>To search for T1D and MS l ...[more]