Ontology highlight
ABSTRACT:
SUBMITTER: Olshen AB
PROVIDER: S-EPMC2259380 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Olshen Adam B AB Gold Bert B Lohmueller Kirk E KE Struewing Jeffery P JP Satagopan Jaya J Stefanov Stefan A SA Eskin Eleazar E Kirchhoff Tomas T Lautenberger James A JA Klein Robert J RJ Friedman Eitan E Norton Larry L Ellis Nathan A NA Viale Agnes A Lee Catherine S CS Borgen Patrick I PI Clark Andrew G AG Offit Kenneth K Boyd Jeff J
BMC genetics 20080205
<h4>Background</h4>Genetic isolates such as the Ashkenazi Jews (AJ) potentially offer advantages in mapping novel loci in whole genome disease association studies. To analyze patterns of genetic variation in AJ, genotypes of 101 healthy individuals were determined using the Affymetrix EAv3 500 K SNP array and compared to 60 CEPH-derived HapMap (CEU) individuals. 435,632 SNPs overlapped and met annotation criteria in the two groups.<h4>Results</h4>A small but significant global difference in alle ...[more]