Ontology highlight
ABSTRACT:
SUBMITTER: Thiviyanathan V
PROVIDER: S-EPMC2262052 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Thiviyanathan Varatharasa V Somasunderam Anoma A Volk David E DE Hazra Tapas K TK Mitra Sankar S Gorenstein David G DG
Biochemical and biophysical research communications 20071217 3
The most abundant base-substitution mutation resulting from oxidative damage to DNA is the GC to AT transition mutation. 5-hydroxyuracil (5-OHU), produced by the oxidative deamination of cystosine, has been established as the major chemical precursor for this most abundant transition mutation. Results from NMR spectroscopy and UV melting experiments show that 5-OHU would form the most stable pair with G, and the least stable pair with C. The hydroxyl group in the 5th position of the 5-OHU residu ...[more]