Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC2262939 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Li Xiaoling X Gao Xue X Liu Guofa G Xiong Wencheng W Wu Jane J Rao Yi Y
Nature neuroscience 20071209 1
Netrins are prototypical axon guidance cues whose attractive signaling requires the small GTPase Rac1. It remains unclear how Rac1 is regulated in the netrin pathway. DOCK180 is a member of a new family of guanine nucleotide exchange factors for Rho GTPases. Here we provide evidence implicating DOCK180 in netrin signal transduction. Netrin promoted the formation of a protein-protein interaction complex that included DOCK180 and the netrin receptor deleted in colorectal carcinoma (DCC). Inhibitio ...[more]