Ontology highlight
ABSTRACT:
SUBMITTER: Scrima A
PROVIDER: S-EPMC2265111 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Scrima Andrea A Thomas Christoph C Deaconescu Delia D Wittinghofer Alfred A
The EMBO journal 20080228 7
The GTP-binding protein Rap1 regulates integrin-mediated and other cell adhesion processes. Unlike most other Ras-related proteins, it contains a threonine in switch II instead of a glutamine (Gln61 in Ras), a residue crucial for the GTPase reaction of most G proteins. Furthermore, unlike most other GTPase-activating proteins (GAPs) for small G proteins, which supply a catalytically important Arg-finger, no arginine residue of RapGAP makes a significant contribution to the GTPase reaction of Rap ...[more]