Defining genetic interaction.
Ontology highlight
ABSTRACT:
SUBMITTER: Mani R
PROVIDER: S-EPMC2265146 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Publications
Defining genetic interaction.
Mani Ramamurthy R St Onge Robert P RP Hartman John L JL Giaever Guri G Roth Frederick P FP
Proceedings of the National Academy of Sciences of the United States of America 20080227 9
Sometimes mutations in two genes produce a phenotype that is surprising in light of each mutation's individual effects. This phenomenon, which defines genetic interaction, can reveal functional relationships between genes and pathways. For example, double mutants with surprisingly slow growth define synergistic interactions that can identify compensatory pathways or protein complexes. Recent studies have used four mathematically distinct definitions of genetic interaction (here termed Product, A ...[more]
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