Ontology highlight
ABSTRACT:
SUBMITTER: Kittler JT
PROVIDER: S-EPMC2265186 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Kittler Josef T JT Chen Guojun G Kukhtina Viktoria V Vahedi-Faridi Ardeschir A Gu Zhenglin Z Tretter Verena V Smith Katharine R KR McAinsh Kristina K Arancibia-Carcamo I Lorena IL Saenger Wolfram W Haucke Volker V Yan Zhen Z Moss Stephen J SJ
Proceedings of the National Academy of Sciences of the United States of America 20080227 9
The regulation of the number of gamma2-subunit-containing GABA(A) receptors (GABA(A)Rs) present at synapses is critical for correct synaptic inhibition and animal behavior. This regulation occurs, in part, by the controlled removal of receptors from the membrane in clathrin-coated vesicles, but it remains unclear how clathrin recruitment to surface gamma2-subunit-containing GABA(A)Rs is regulated. Here, we identify a gamma2-subunit-specific Yxxvarphi-type-binding motif for the clathrin adaptor p ...[more]