Ontology highlight
ABSTRACT:
SUBMITTER: Jauregui AR
PROVIDER: S-EPMC2265406 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
The Journal of cell biology 20080303 5
Nephronophthisis (NPHP) is the most common genetic cause of end-stage renal disease in children and young adults. In Chlamydomonas reinhardtii, Caenorhabditis elegans, and mammals, the NPHP1 and NPHP4 gene products nephrocystin-1 and nephrocystin-4 localize to basal bodies or ciliary transition zones (TZs), but their function in this location remains unknown. We show here that loss of C. elegans NPHP-1 and NPHP-4 from TZs is tolerated in developing cilia but causes changes in localization of spe ...[more]