The Caenorhabditis elegans nephrocystins act as global modifiers of cilium structure.
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ABSTRACT:
SUBMITTER: Jauregui AR
PROVIDER: S-EPMC2265406 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Publications
The Caenorhabditis elegans nephrocystins act as global modifiers of cilium structure.
Jauregui Andrew R AR Nguyen Ken C Q KC Hall David H DH Barr Maureen M MM
The Journal of cell biology 20080303 5
Nephronophthisis (NPHP) is the most common genetic cause of end-stage renal disease in children and young adults. In Chlamydomonas reinhardtii, Caenorhabditis elegans, and mammals, the NPHP1 and NPHP4 gene products nephrocystin-1 and nephrocystin-4 localize to basal bodies or ciliary transition zones (TZs), but their function in this location remains unknown. We show here that loss of C. elegans NPHP-1 and NPHP-4 from TZs is tolerated in developing cilia but causes changes in localization of spe ...[more]
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