Bex1 knock out mice show altered skeletal muscle regeneration.
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ABSTRACT:
SUBMITTER: Koo JH
PROVIDER: S-EPMC2265538 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Publications
Bex1 knock out mice show altered skeletal muscle regeneration.
Koo Jae Hyung JH Smiley Mark A MA Lovering Richard M RM Margolis Frank L FL
Biochemical and biophysical research communications 20070911 2
Bex1 and Calmodulin (CaM) are upregulated during skeletal muscle regeneration. We confirm this finding and demonstrate the novel finding that they interact in a calcium-dependent manner. To study the role of Bex1 and its interaction with CaM in skeletal muscle regeneration, we generated Bex1 knock out (Bex1-KO) mice. These mice appeared to develop normally and are fertile, but displayed a functional deficit in exercise performance compared to wild type (WT) mice. After intramuscular injection of ...[more]
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