Ontology highlight
ABSTRACT:
SUBMITTER: Blagoveshchenskaya A
PROVIDER: S-EPMC2265582 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Blagoveshchenskaya Anastasia A Cheong Fei Ying FY Rohde Holger M HM Glover Greta G Knödler Andreas A Nicolson Teresa T Boehmelt Guido G Mayinger Peter P
The Journal of cell biology 20080201 4
When a growing cell expands, lipids and proteins must be delivered to its periphery. Although this phenomenon has been observed for decades, it remains unknown how the secretory pathway responds to growth signaling. We demonstrate that control of Golgi phosphatidylinositol-4-phosphate (PI(4)P) is required for growth-dependent secretion. The phosphoinositide phosphatase SAC1 accumulates at the Golgi in quiescent cells and down-regulates anterograde trafficking by depleting Golgi PI(4)P. Golgi loc ...[more]