Ontology highlight
ABSTRACT:
SUBMITTER: Cho JH
PROVIDER: S-EPMC22666 | biostudies-literature | 1998 Jun
REPOSITORIES: biostudies-literature
Cho J H JH Nicolae D L DL Gold L H LH Fields C T CT LaBuda M C MC Rohal P M PM Pickles M R MR Qin L L Fu Y Y Mann J S JS Kirschner B S BS Jabs E W EW Weber J J Hanauer S B SB Bayless T M TM Brant S R SR
Proceedings of the National Academy of Sciences of the United States of America 19980601 13
The idiopathic inflammatory bowel diseases, Crohn's disease (CD) and ulcerative colitis (UC), are chronic, frequently disabling diseases of the intestines. Segregation analyses, twin concordance, and ethnic differences in familial risks have established that CD and UC are complex, non-Mendelian, related genetic disorders. We performed a genome-wide screen using 377 autosomal markers, on 297 CD, UC, or mixed relative pairs from 174 families, 37% Ashkenazim. We observed evidence for linkage at 3q ...[more]