Ontology highlight
ABSTRACT:
SUBMITTER: Wu C
PROVIDER: S-EPMC2267236 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Wu Chenyi C Bassett Andrew A Travers Andrew A
EMBO reports 20071201 12
The structure of the 30-nm chromatin fibre is an important determinant of the regulation of eukaryotic transcription. A fundamental issue is whether the stacking of nucleosomes in this fibre is organized as a one-start or two-start helix. We argue that all recent experimental data are compatible with a two-start helix and propose that the topology of the fibre, but not the mode of stacking the nucleosomes, is dependent on the length of the linker DNA. This arrangement conserves nucleosome stacki ...[more]