Ontology highlight
ABSTRACT:
SUBMITTER: Blackledge NP
PROVIDER: S-EPMC2267356 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Blackledge Neil P NP Carter Emma J EJ Evans Joanne R JR Lawson Victoria V Rowntree Rebecca K RK Harris Ann A
The Biochemical journal 20071201 2
Regulatory elements that lie outside the basal promoter of a gene may be revealed by local changes in chromatin structure and histone modifications. The promoter of the CFTR (cystic fibrosis transmembrane conductance regulator) gene is not responsible for its complex pattern of expression. To identify important regulatory elements for CFTR we have previously mapped DHS (DNase I-hypersensitive sites) across 400 kb spanning the locus. Of particular interest were two DHS that flank the CFTR gene, u ...[more]