Unknown

Dataset Information

0

Effects of cholesterol ester transfer protein (CETP) gene on adiposity in response to long-term overfeeding.


ABSTRACT: Cholesterol ester transfer protein (CETP) plays a key role in remodeling triglyceride-rich particles and high-density lipoproteins (HDL). We investigated CETP sequence variants in response to long-term overfeeding (100 days) in 12 pairs of male monozygotic twins (mean age+/-S.D.: 21+/-2 years). Body fat mass (FM), abdominal subcutaneous (ASF) and visceral fat (AVF), and plasma lipoproteins were determined. The CETP variants C>T/In9 (rs289714) and G>A/Ex14 (rs5882, or I405V) were investigated by RFLP-PCR methodologies. Before overfeeding, the CETP CC/In9 (n=18) genotype was associated with lower FM compared to the C>T/In9 heterozygotes. Overfeeding induced more FM and ASF accretion in C>T/In9 carriers (P

SUBMITTER: Teran-Garcia M 

PROVIDER: S-EPMC2267371 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Effects of cholesterol ester transfer protein (CETP) gene on adiposity in response to long-term overfeeding.

Terán-García Margarita M   Després Jean-Pierre JP   Tremblay Angelo A   Bouchard Claude C  

Atherosclerosis 20061228 1


Cholesterol ester transfer protein (CETP) plays a key role in remodeling triglyceride-rich particles and high-density lipoproteins (HDL). We investigated CETP sequence variants in response to long-term overfeeding (100 days) in 12 pairs of male monozygotic twins (mean age+/-S.D.: 21+/-2 years). Body fat mass (FM), abdominal subcutaneous (ASF) and visceral fat (AVF), and plasma lipoproteins were determined. The CETP variants C>T/In9 (rs289714) and G>A/Ex14 (rs5882, or I405V) were investigated by  ...[more]

Similar Datasets

| S-EPMC6580557 | biostudies-literature
| S-EPMC9464954 | biostudies-literature
| S-EPMC4789658 | biostudies-literature
| S-EPMC3269125 | biostudies-literature
| S-EPMC6559892 | biostudies-literature
| S-EPMC6761010 | biostudies-literature
| S-EPMC3720705 | biostudies-literature
| S-EPMC8463530 | biostudies-literature
| S-EPMC2766633 | biostudies-literature
| S-EPMC1134687 | biostudies-other