Ribosomal proteins are targets for the NEDD8 pathway.
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ABSTRACT:
SUBMITTER: Xirodimas DP
PROVIDER: S-EPMC2267383 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Publications
Ribosomal proteins are targets for the NEDD8 pathway.
Xirodimas Dimitris P DP Sundqvist Anders A Nakamura Akihiro A Shen Linnan L Botting Catherine C Hay Ronald T RT
EMBO reports 20080215 3
Identification of the molecular targets for post-translational modifications is an important step for explaining the regulated pathways. The ubiquitin-like molecule NEDD8 is implicated in the regulation of cell proliferation, viability and development. By combining proteomics and in vivo NEDDylation assays, we identified a subset of ribosomal proteins as novel targets for the NEDD8 pathway. We further show that the lack of NEDDylation in cells causes ribosomal protein instability. Our studies id ...[more]
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