Ontology highlight
ABSTRACT:
SUBMITTER: Goh AM
PROVIDER: S-EPMC2267792 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Goh Amanda M AM Walters Kylie J KJ Elsasser Suzanne S Verma Rati R Deshaies Raymond J RJ Finley Daniel D Howley Peter M PM
BMC biochemistry 20080130
<h4>Background</h4>The delivery of ubiquitinated proteins to the proteasome for degradation is a key step in the regulation of the ubiquitin-proteasome pathway, yet the mechanisms underlying this step are not understood in detail. The Rad23 family of proteins is known to bind ubiquitinated proteins through its two ubiquitin-associated (UBA) domains, and may participate in the delivery of ubiquitinated proteins to the proteasome through docking via the Rad23 ubiquitin-like (UBL) domain.<h4>Result ...[more]