Ontology highlight
ABSTRACT:
SUBMITTER: Stumpff J
PROVIDER: S-EPMC2267861 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Stumpff Jason J von Dassow George G Wagenbach Michael M Asbury Charles C Wordeman Linda L
Developmental cell 20080201 2
During vertebrate cell division, chromosomes oscillate with periods of smooth motion interrupted by abrupt reversals in direction. These oscillations must be spatially constrained in order to align and segregate chromosomes with high fidelity, but the molecular mechanism for this activity is uncertain. We report here that the human kinesin-8 Kif18A has a primary role in the control of chromosome oscillations. Kif18A accumulates as a gradient on kinetochore microtubules in a manner dependent on i ...[more]