Ontology highlight
ABSTRACT:
SUBMITTER: Newberg LA
PROVIDER: S-EPMC2268014 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Newberg Lee A LA Thompson William A WA Conlan Sean S Smith Thomas M TM McCue Lee Ann LA Lawrence Charles E CE
Bioinformatics (Oxford, England) 20070508 14
<h4>Motivation</h4>Identification of functionally conserved regulatory elements in sequence data from closely related organisms is becoming feasible, due to the rapid growth of public sequence databases. Closely related organisms are most likely to have common regulatory motifs; however, the recent speciation of such organisms results in the high degree of correlation in their genome sequences, confounding the detection of functional elements. Additionally, alignment algorithms that use optimiza ...[more]