Ontology highlight
ABSTRACT:
SUBMITTER: Lee KP
PROVIDER: S-EPMC2268165 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Lee Kwang Pum KP Simpson Stephen J SJ Clissold Fiona J FJ Brooks Robert R Ballard J William O JW Taylor Phil W PW Soran Nazaneen N Raubenheimer David D
Proceedings of the National Academy of Sciences of the United States of America 20080211 7
Modest dietary restriction (DR) prolongs life in a wide range of organisms, spanning single-celled yeast to mammals. Here, we report the use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster. Caloric restriction (CR) was not responsible for extending lifespan in our experimental flies. Response surfaces for lifespan and fecundity were maximized at different protein-carbohydrate int ...[more]