Barhl1 regulatory sequences required for cell-specific gene expression and autoregulation in the inner ear and central nervous system.

ABSTRACT: The development of the nervous system requires the concerted actions of multiple transcription factors, yet the molecular events leading to their expression remain poorly understood. Barhl1, a mammalian homeodomain transcription factor of the BarH class, is expressed by developing inner ear hair cells, cerebellar granule cells, precerebellar neurons, and collicular neurons. Targeted gene inactivation has demonstrated a crucial role for Barhl1 in the survival and/or migration of these sensory cells and neurons. Here we report the regulatory sequences of Barhl1 necessary for directing its proper spatiotemporal expression pattern in the inner ear and central nervous system (CNS). Using a transgenic approach, we have found that high-level and cell-specific expression of Barhl1 within the inner

SUBMITTER: Chellappa R 

PROVIDER: S-EPMC2268402 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature