Ontology highlight
ABSTRACT:
SUBMITTER: Marcondes AM
PROVIDER: S-EPMC2268551 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Marcondes A Mario AM Mhyre Andrew J AJ Stirewalt Derek L DL Kim Soo-Hyun SH Dinarello Charles A CA Deeg H Joachim HJ
Proceedings of the National Academy of Sciences of the United States of America 20080219 8
TNFalpha levels are elevated in the marrows of patients with myelodysplastic syndrome (MDS) and are associated with high rates of apoptosis, which contributes to hematopoietic failure. We observed that exposure of human marrow stroma cell lines HS5 and HS27a to TNFalpha increases levels of IL-32 mRNA. IL-32, in turn, induces TNFalpha. Marrow stroma from patients with MDS expressed 14- to 17-fold higher levels of IL-32 mRNA than healthy controls. In contrast, cells from patients with chronic myel ...[more]