Ontology highlight
ABSTRACT:
SUBMITTER: Papatsenko D
PROVIDER: S-EPMC2268557 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Papatsenko Dmitri D Levine Michael S MS
Proceedings of the National Academy of Sciences of the United States of America 20080219 8
The regulation of segmentation gene expression is investigated by computational modeling using quantitative expression data. Previous tissue culture assays and transgene analyses raised the possibility that Hunchback (Hb) might function as both an activator and repressor of transcription. At low concentrations, Hb activates gene expression, whereas at high concentrations it mediates repression. Under the same experimental conditions, transcription factors encoded by other gap genes appear to fun ...[more]