Ontology highlight
ABSTRACT:
SUBMITTER: Ramessar K
PROVIDER: S-EPMC2268773 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Ramessar Koreen K Rademacher Thomas T Sack Markus M Stadlmann Johannes J Platis Dimitris D Stiegler Gabriela G Labrou Nikos N Altmann Fritz F Ma Julian J Stöger Eva E Capell Teresa T Christou Paul P
Proceedings of the National Academy of Sciences of the United States of America 20080303 10
A series of small-molecule microbicides has been developed for vaginal delivery to prevent heterosexual HIV transmission, but results from human clinical trials have been disappointing. Protein-based microbicides, such as HIV-specific monoclonal antibodies, have been considered as an alternative approach. Despite their promising safety profile and efficacy, the major drawback of such molecules is the economy of large-scale production in mammalian cells, the current system of choice. Here, we sho ...[more]