Ontology highlight
ABSTRACT:
SUBMITTER: Griffioen M
PROVIDER: S-EPMC2268788 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Griffioen Marieke M van der Meijden Edith D ED Slager Elisabeth H EH Honders M Willy MW Rutten Caroline E CE van Luxemburg-Heijs Simone A P SA von dem Borne Peter A PA van Rood Johannes J JJ Willemze Roel R Falkenburg J H Frederik JH
Proceedings of the National Academy of Sciences of the United States of America 20080303 10
Patients with hematological malignancies can be successfully treated with HLA-matched T cell-depleted allogeneic stem cell transplantation (alloSCT) and subsequent donor lymphocyte infusions (DLIs). The efficacy of DLI is mediated by donor T cells recognizing minor histocompatibility antigens (mHags) on malignant recipient cells. Because HLA class II molecules are predominantly expressed on hematopoietic cells, mHag-specific CD4(+) T cells may selectively mediate graft versus leukemia (GvL) reac ...[more]