Ontology highlight
ABSTRACT:
SUBMITTER: St Clair EW
PROVIDER: S-EPMC2269728 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20080401 4
In March 2006, a phase I study of the superagonistic anti-CD28 antibody TGN1412 caused a massive cytokine storm and multiorgan failure in six healthy human volunteers. Such a profound impact on the immune system was not predicted by preclinical animal studies. In a study from this issue of the JCI, Müller et al. treated rats with the superagonistic anti-CD28 antibody JJ316 and found that it rapidly induced a marked T cell lymphopenia by trapping T cells in the spleen and lymph nodes (see the rel ...[more]