Ontology highlight
ABSTRACT:
SUBMITTER: Daley E
PROVIDER: S-EPMC2271018 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Daley Eleen E Emson Claire C Guignabert Christophe C de Waal Malefyt Rene R Louten Jennifer J Kurup Viswanath P VP Hogaboam Cory C Taraseviciene-Stewart Laimute L Voelkel Norbert F NF Rabinovitch Marlene M Grunig Ekkehard E Grunig Gabriele G
The Journal of experimental medicine 20080128 2
Pulmonary arterial remodeling characterized by increased vascular smooth muscle density is a common lesion seen in pulmonary arterial hypertension (PAH), a deadly condition. Clinical correlation studies have suggested an immune pathogenesis of pulmonary arterial remodeling, but experimental proof has been lacking. We show that immunization and prolonged intermittent challenge via the airways with either of two different soluble antigens induced severe muscularization in small- to medium-sized pu ...[more]