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KARP-1 is induced by DNA damage in a p53- and ataxia telangiectasia mutated-dependent fashion.

ABSTRACT: The KARP-1 (Ku86 Autoantigen Related Protein-1) gene, which is expressed from the human Ku86 autoantigen locus, appears to play a role in mammalian DNA double-strand break repair as a regulator of the DNA-dependent protein kinase complex. Here we demonstrate that KARP-1 gene expression is significantly up-regulated following exposure of cells to DNA damage. KARP-1 mRNA induction was completely dependent on the ataxia telangiectasia and p53 gene products, consistent with the presence of a p53 binding site within the second intron of the KARP-1 locus. These observations link ataxia telangiectasia, p53, and KARP-1 in a common pathway.

SUBMITTER: Myung K

PROVIDER: S-EPMC22716 | biostudies-literature | 1998 Jun

REPOSITORIES: biostudies-literature

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KARP-1 is induced by DNA damage in a p53- and ataxia telangiectasia mutated-dependent fashion.

Myung K K Braastad C C He D M DM Hendrickson E A EA

Proceedings of the National Academy of Sciences of the United States of America 19980601 13

The KARP-1 (Ku86 Autoantigen Related Protein-1) gene, which is expressed from the human Ku86 autoantigen locus, appears to play a role in mammalian DNA double-strand break repair as a regulator of the DNA-dependent protein kinase complex. Here we demonstrate that KARP-1 gene expression is significantly up-regulated following exposure of cells to DNA damage. KARP-1 mRNA induction was completely dependent on the ataxia telangiectasia and p53 gene products, consistent with the presence of a p53 bin ...[more]

PMID: 9636207

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