Ontology highlight
ABSTRACT:
SUBMITTER: Mollica A
PROVIDER: S-EPMC2274921 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20070601 13
Ring-closing metathesis has emerged as a powerful tool in organic synthesis for generating cyclic structures via C-C double bond formation. Recently, it has been successfully used in peptide chemistry for obtaining cyclic molecules bridged through an olefin unit in place of the usual disulfide bond. Here, we describe this approach for obtaining cyclic olefin bridged analogues of H-Tyr-c[D-Cys-Gly-Phe-Cys]-OH. The synthesis of the new ligands was performed using the second generation Grubbs' cata ...[more]