Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC2275017 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Li Xiaochun X Stankovic Milena M Bonder Claudine S CS Hahn Christopher N CN Parsons Michelle M Pitson Stuart M SM Xia Pu P Proia Richard L RL Vadas Mathew A MA Gamble Jennifer R JR
Blood 20080116 7
Endothelial cells (ECs) regulate the barrier function of blood vessels. Here we show that basal and angiopoietin-1 (Ang-1)-regulated control of EC permeability is mediated by 2 different functional states of sphingosine kinase-1 (SK-1). Mice depleted of SK-1 have increased vascular leakiness, whereas mice transgenic for SK-1 in ECs show attenuation of leakiness. Furthermore, Ang-1 rapidly and transiently stimulates SK-1 activity and phosphorylation, and induces an increase in intracellular sphin ...[more]