Ontology highlight
ABSTRACT:
SUBMITTER: Reiter NJ
PROVIDER: S-EPMC2275087 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Reiter Nicholas J NJ Maher L James LJ Butcher Samuel E SE
Nucleic acids research 20071226 4
The binding of RNA molecules to proteins or other ligands can require extensive RNA folding to create an induced fit. Understanding the generality of this principle involves comparing structures of RNA before and after complex formation. Here we report the NMR solution structure of a 29-nt RNA aptamer whose crystal structure had previously been determined in complex with its transcription factor target, the p50(2) form of NF-kappaB. The RNA aptamer internal loop structure has pre-organized featu ...[more]