Ontology highlight
ABSTRACT:
SUBMITTER: Shriner D
PROVIDER: S-EPMC2275105 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Shriner Daniel D Baye Tesfaye M TM Padilla Miguel A MA Zhang Shiju S Vaughan Laura K LK Loraine Ann E AE
Nucleic acids research 20080207 4
Linkage studies of complex traits frequently yield multiple linkage regions covering hundreds of genes. Testing each candidate gene from every region is prohibitively expensive and computational methods that simplify this process would benefit genetic research. We present a new method based on commonality of functional annotation (CFA) that aids dissection of complex traits for which multiple causal genes act in a single pathway or process. CFA works by testing individual Gene Ontology (GO) term ...[more]