Ontology highlight
ABSTRACT:
SUBMITTER: Bogdanova E
PROVIDER: S-EPMC2275141 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Bogdanova Ekaterina E Djordjevic Marko M Papapanagiotou Ioanna I Heyduk Tomasz T Kneale Geoff G Severinov Konstantin K
Nucleic acids research 20080118 5
The Restriction-modification system AhdI contains two convergent transcription units, one with genes encoding methyltransferase subunits M and S and another with genes encoding the controller (C) protein and the restriction endonuclease (R). We show that AhdI transcription is controlled by two independent regulatory loops that are well-optimized to ensure successful establishment in a naïve bacterial host. Transcription from the strong MS promoter is attenuated by methylation of an AhdI site ove ...[more]