Ontology highlight
ABSTRACT:
SUBMITTER: Buerki C
PROVIDER: S-EPMC2275151 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Buerki Christine C Rothgiesser Karin M KM Valovka Taras T Owen Heather R HR Rehrauer Hubert H Fey Monika M Lane William S WS Hottiger Michael O MO
Nucleic acids research 20080207 5
Nuclear factor kappaB (NF-kappaB) plays an important role in the transcriptional regulation of genes involved in immunity and cell survival. We show here in vitro and in vivo acetylation of RelA/p65 by p300 on lysine 314 and 315, two novel acetylation sites. Additionally, we confirmed the acetylation on lysine 310 shown previously. Genetic complementation of RelA/p65-/- cells with wild type and non-acetylatable mutants of RelA/p65 (K314R and K315R) revealed that neither shuttling, DNA binding no ...[more]