Ontology highlight
ABSTRACT:
SUBMITTER: Wasserstrom A
PROVIDER: S-EPMC2275312 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
PLoS computational biology 20080509 4
The depth of a cell of a multicellular organism is the number of cell divisions it underwent since the zygote, and knowing this basic cell property would help address fundamental problems in several areas of biology. At present, the depths of the vast majority of human and mouse cell types are unknown. Here, we show a method for estimating the depth of a cell by analyzing somatic mutations in its microsatellites, and provide to our knowledge for the first time reliable depth estimates for severa ...[more]