Ontology highlight
ABSTRACT:
SUBMITTER: Kretzschmar B
PROVIDER: S-EPMC2276251 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Kretzschmar Benedikt B Nowrouzi Ali A Hartl Maximilian J MJ Gärtner Kathleen K Wiktorowicz Tatiana T Herchenröder Ottmar O Kanzler Sylvia S Rudolph Wolfram W Mergia Ayalew A Wöhrl Birgitta B Rethwilm Axel A
Virology 20070927 1
Azidothymidine (AZT) is a reverse transcriptase (RT) inhibitor that efficiently blocks the replication of spumaretroviruses or foamy viruses (FVs). To more precisely elucidate the mechanism of action of the FV RT enzyme, we generated an AZT-resistant FV in cell culture. Biologically resistant virus was obtained for simian foamy virus from macaque (SFVmac), which was insensitive to AZT concentrations of 1 mM, but not for FVs derived from chimpanzees. Nucleotide sequencing revealed four non-silent ...[more]