Ontology highlight
ABSTRACT:
SUBMITTER: Bose M
PROVIDER: S-EPMC2276375 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Bose Mahuya M Whittal Randy M RM Miller Walter L WL Bose Himangshu S HS
The Journal of biological chemistry 20080204 14
The steroidogenic acute regulatory protein (StAR) is required for adrenal and gonadal steroidogenesis and for male sexual differentiation. StAR acts on the outer mitochondrial membrane (OMM) to facilitate movement of cholesterol from the OMM to the inner mitochondrial membrane to be converted to pregnenolone, the precursor of all steroid hormones. The mechanisms of the action of StAR remain unclear; the peripheral benzodiazepine receptor, an OMM protein, appears to be involved, but the identity ...[more]