Ontology highlight
ABSTRACT:
SUBMITTER: Kuo CJ
PROVIDER: S-EPMC2276626 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Journal of biomedicine & biotechnology 20080101
Helicobacter pylori colonizes the human gastric epithelium and causes diseases such as gastritis, peptic ulcers, and stomach cancer. Undecaprenyl pyrophosphate synthase (UPPS), which catalyzes consecutive condensation reactions of farnesyl pyrophosphate with eight isopentenyl pyrophosphate to form lipid carrier for bacterial peptidoglycan biosynthesis, represents a potential target for developing new antibiotics. In this study, we solved the crystal structure of H. pylori UPPS and performed virt ...[more]