Ontology highlight
ABSTRACT:
SUBMITTER: Abdeltawab NF
PROVIDER: S-EPMC2277464 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Abdeltawab Nourtan F NF Aziz Ramy K RK Kansal Rita R Rowe Sarah L SL Su Yin Y Gardner Lidia L Brannen Charity C Nooh Mohammed M MM Attia Ramy R RR Abdelsamed Hossam A HA Taylor William L WL Lu Lu L Williams Robert W RW Kotb Malak M
PLoS pathogens 20080418 4
Striking individual differences in severity of group A streptococcal (GAS) sepsis have been noted, even among patients infected with the same bacterial strain. We had provided evidence that HLA class II allelic variation contributes significantly to differences in systemic disease severity by modulating host responses to streptococcal superantigens. Inasmuch as the bacteria produce additional virulence factors that participate in the pathogenesis of this complex disease, we sought to identify ad ...[more]