Ontology highlight
ABSTRACT:
SUBMITTER: Saneyoshi T
PROVIDER: S-EPMC2277504 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Saneyoshi Takeo T Wayman Gary G Fortin Dale D Davare Monika M Hoshi Naoto N Nozaki Naohito N Natsume Tohru T Soderling Thomas R TR
Neuron 20080101 1
Neuronal activity augments maturation of mushroom-shaped spines to form excitatory synapses, thereby strengthening synaptic transmission. We have delineated a Ca(2+)-signaling pathway downstream of the NMDA receptor that stimulates calmodulin-dependent kinase kinase (CaMKK) and CaMKI to promote formation of spines and synapses in hippocampal neurons. CaMKK and CaMKI form a multiprotein signaling complex with the guanine nucleotide exchange factor (GEF) betaPIX and GIT1 that is localized in spine ...[more]